Research, Development & Innovation

Providing new knowledge and helping us provide the best possible care.

The Royal Cornwall Hospitals Research, Development and Innovation department supports and facilitates health research in Cornwall. Research is a hugely important part of what we do at the Royal Cornwall Hospitals. It gives us new knowledge about how to treat and care for patients with different health conditions and helps us to provide our patients with the best and most appropriate care possible.
We are dedicated to developing ground breaking treatments, technologies and techniques as well as meeting your needs and identifying the best use of resources.

More about the department

Find out how our research team is helping improve rehabilitation for people with chronic heart failure

How we approve research and make sure it is safe

  • The NHS Research Governance Framework sets out the standards by which research is conducted, including the monitoring of protocols and procedures to make sure that these are followed.
  • Any research we carry out must meet recognised ethical standards and respect the dignity, rights, safety and well-being of the people who take part.
  • These standards must be assessed and approved by an independent Research Ethics Committee (REC)

Links to further information on clinical research

Newsletters


Links to some of our previous studies

Please see below sample of published research results from some of the studies that the Royal Cornwall Hospitals Trust have been involved in. We are aiming to increase the number available on this webpage in the future.

Please note there is often a significant time lag between the end of patient participation in a study and the availability of the results.

Cardiology

HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/ laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment
http://epadruginitiative.com/files/HPS2_THRIVE_Study.pdf
Rehabilitation Enablement in Chronic Heart Failure (REACH-HF)
https://www.royalcornwall.nhs.uk/services/research-development-innovation/rehabilitation-enablement-chronic-heart-failure-reach-hf/

Critical Care

Risk Adjustment In Neurocritical care (RAIN)–prospective validation of risk prediction models for adult patients with acute traumatic brain injury to use to evaluate the optimum location and comparative costs of neurocritical care: a cohort study.
https://www.ncbi.nlm.nih.gov/pubmed/23763763

Dermatology

Effect of Topical Imiquimod as Primary Treatment for Lentigo Maligna: The LIMIT-1 Study
https://www.ncbi.nlm.nih.gov/labs/articles/27714781/

Diabetes

ALTITUDE: ALiskiren Trail in T2 Diabetes using cardiorenal endpoints
https://clinicaltrials.gov/ct2/show/results/NCT00549757

Emergency Medicine

Randomised Evaluation of modified Valsalva Effectiveness in Re-entrant Tachycardias (REVERT) study.
https://www.ncbi.nlm.nih.gov/pubmed/24622951

Haematology

Myeloma XI- Randomised comparisons in myeloma patients of all ages of thalidomide, lenalidomide and bortezomib combinations and maintenance lenalidomide
https://www.myeloma.org.uk/news/myeloma-xi-trial-results-show-significant-increase-in-myeloma-patient-remission/

Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy
http://www.nejm.org/doi/full/10.1056/NEJMoa1616569

Hepatology

Hepatitis E virus in patients with decompensated chronic liver disease: a prospective UK/French study.
https://www.ncbi.nlm.nih.gov/pubmed/26174470

Steroids or Pentoxifylline for Alcoholic Hepatitis (STOPAH) trial
http://www.medscape.com/viewarticle/834928

Neurology- Multiple Sclerosis

The Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) trial: a randomised double-blind placebo-controlled parallel-group multicentre trial and economic evaluation of cannabinoids to slow progression in multiple sclerosis.
https://www.ncbi.nlm.nih.gov/pubmed/25676540

Towards a better understanding of MS pain: a systematic review of potentially modifiable psychosocial factors.
https://www.ncbi.nlm.nih.gov/pubmed/25438982

Oncology

Intermittent chemotherapy plus either intermittent or continuous cetuximab for first-line treatment of patients with KRAS wild-type advanced colorectal cancer (COIN-B): a randomised phase 2 trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012566/

Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159416/

Paediatrics

MAGNEsium Trial In Children (MAGNETIC): a randomised, placebo-controlled trial and economic evaluation of nebulised magnesium sulphate in acute severe asthma in children
https://www.ncbi.nlm.nih.gov/pubmed/24144222

Oxygen saturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00163-4/fulltext?rss=yes

Rheumatology

A Survey of Psychological Support Provision for People with Inflammatory Arthritis in Secondary Care in England- PSYSCOPE
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282402/

Stroke

Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial
http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)70018-9/abstract

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61121-1/abstract

TWIST: Does the Use of Nintendo Wii SportsTM Improve Arm Function? Trial of WiiTM in Stroke: A Randomized Controlled Trial and Economics Analysis
https://www.ncbi.nlm.nih.gov/labs/articles/26975313/

Women’s Health & Obstetrics

Intraoperative cell salvaged blood as part of a blood conservation strategy in Caesarean section: is fetal red cell contamination important?
https://www.ncbi.nlm.nih.gov/pubmed/21676894

Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00724-2/abstract

Upright versus lying down position in second stage of labour in nulliparous women with low dose epidural: BUMPES randomised controlled trial http://www.bmj.com/content/359/bmj.j4471

Early or Delayed Enteral Feeding for Preterm Growth-Restricted Infants: A Randomised Trial ADEPT http://pediatrics.aappublications.org/content/early/2012/04/04/peds.2011-2379

Oxygen saturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00163-4/fulltext

Oxygen Saturation and Outcomes in Preterm Infants (BOOST II)
http://www.nejm.org/doi/full/10.1056/NEJMoa1302298#t=article

Links to reports on our performance in delivering research

RESEARCH NEWS, EVENTS & AWARDS
News / Cancer Services / Research

New research facility opens at Sunrise Centre

Published: July 26, 2017

Categories: News / Cancer Services / Research

Cancer patients in Cornwall will now have even wider opportunities to access the latest treatments and take part in cancer trials with the opening

News / Research

The Safetxt study

Published: July 24, 2017

Categories: News / Research

In yet another example of the growing portfolio of research studies at RCHT, Olivia Dunlop, the RCHT Chlamydia Screening promotion worker

Award / Awards and Achievements / Research

Celebrating Innovation at the 2nd Annual Research Awards

Published: January 31, 2018

Categories: Award / Awards and Achievements / Research

On Friday, NHS staff involved in research from across Cornwall gathered to celebrate successes at the 2nd annual Research Awards.