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Research & Development

This page was last updated: November 17th, 2022

The Royal Cornwall Hospitals Research and Development department supports and facilitates health research in Cornwall. Research is a hugely important part of what we do at the Royal Cornwall Hospitals. It gives us new knowledge about how to treat and care for patients with different health conditions and helps us to provide our patients with the best and most appropriate care possible.

We are dedicated to developing ground breaking treatments, technologies and techniques as well as meeting your needs and identifying the best use of resources.

Find out about health and social care research that is taking place in your area and across the UK.

Enrolling Adults Age 65+ Now:

A Clinical Trial for Seasonal Flu

Sites near you are looking for participants for the Glow Trial, a clinical trial for an investigational messenger RNA (mRNA) vaccine aimed at preventing seasonal flu infection. You have the power to potentially change the future of seasonal flu with 1 injection.

The Potential of mRNA Vaccines

Currently approved seasonal flu vaccines are usually only up to 60% effective, and they often perform poorly during years when the circulating flu strains don’t match the strains selected for that year’s vaccine.1 An mRNA vaccine has the potential to offer broader protection by responding to strain changes more quickly, creating stronger immune responses and improving protection in older adults.2

Right now, research is underway to evaluate an investigational mRNA-based flu vaccine to see if it is effective. Moderna is studying the mRNA-1010 investigational vaccine to understand whether it can help your body’s immune system protect against seasonal flu.

Who Can Join?

This clinical trial is looking for adult participants. To join, you must be:

  • Age 65 or older
  • Able to follow participation instructions
  • Not pregnant or planning on becoming pregnant for at least 3 months following your vaccine visit (as appropriate)

Other criteria may apply in order to be eligible.

What to Expect

Your participation in the Glow Trial should last about 13 months.

  • It will include up to 3 trial visits and up to 6 phone calls to check in about any side effects
  • Participants will be given 1 injection in the upper arm. Each participant has a 50% chance of getting the investigational vaccine and a 50% chance of getting a currently approved seasonal flu vaccine – like tossing a coin
  • Participants must provide information about their health status and whether they experience any flu symptoms by entering information into a symptom-reporting electronic diary, or eDiary. Participants will provide information on their health status every day for the first 7 days after receiving the injection. Then for about the first 6 months, participants will report symptoms in the symptom-reporting eDiary twice a week. For the next 6 months, participants will report symptoms once a week
  • Enrolling in this clinical trial is completely your choice. You may stop participating in the clinical trial at any time, and you do not have to give a reason for doing so
  • Compensation for your trial-related time may be provided

Diseases do not discriminate – and neither should clinical trials
Moderna is committed to researching safe and effective mRNA-based vaccines and therapies to bring better health and living to people of all ages, sexes and backgrounds.

Contact the Glow Trial Team Today to learn more about joining the clinical trial.

Research Department, Royal Cornwall Hospitals Trust
Tel: 07880464139

  1. Belongia EA, Simpson MD, King JP, et al. Variable influenza vaccine effectiveness by subtype: a systematic review and meta-analysis of test-negative design studies. Lancet Infect Dis. 2016;16(8):942-951. doi:10.1016/S1473-3099(16)00129-8
  2. Rockman S, Laurie KL, Parkes S, Wheatley A, Barr IG. New technologies for influenza vaccines. Microorganisms. 2020;8(11):1745.
More about the department

How we approve research and make sure it is safe

  • The NHS Research Governance Framework sets out the standards by which research is conducted. This includes the monitoring of protocols and procedures to make sure that these are followed.
  • Any research we carry out must meet recognised ethical standards and respect the dignity, rights, safety and well-being of the people who take part.
  • These standards must be assessed and approved by an independent Research Ethics Committee (REC)

Links to further information on clinical research

Patient Information and health and care research

Links to some of our previous studies

Please see below sample of published research results from some of the studies that the Royal Cornwall Hospitals Trust have been involved in. We are aiming to increase the number available on this webpage in the future.

Please note there is often a significant time lag between the end of patient participation in a study and the availability of the results.


PROBESE- Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Manuevers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial


HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/ laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment.

Rehabilitation Enablement in Chronic Heart Failure (REACH-HF)

ORION 4- Life-saving anti-cholesterol drug recommended on NHS thanks to groundbreaking clinical trials.


REMAP-CAP- A Randomised, Embedded, Multi-factorial, Adaptive Platform Trial for Community-Acquired Pneumonia.

COMMFLUCOV Study- Combining Influenza and COVID-19 Vaccination (ComFluCOV)

GenOMICC- Another life-saving Covid drug identified.

Novavax- Novavax COVID-19 vaccine researched in the South West approved in UK by MHRA.

Recovery- Results.

Critical Care

Risk Adjustment In Neurocritical care (RAIN)– prospective validation of risk prediction models for adult patients with acute traumatic brain injury to use to evaluate the optimum location and comparative costs of neurocritical care: a cohort study.

POPPI– A nurse-led, preventive, psychological intervention to reduce Post Traumatic Stress Disorder symptom severity in critically ill patients.


Effect of Topical Imiquimod as Primary Treatment for Lentigo Maligna: The LIMIT-1 Study


ALTITUDE: ALiskiren Trail in T2 Diabetes using cardiorenal endpoints

ADDRESS 2- Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort

Emergency Medicine


PANTS Personalised anti-TNF therapy in Crohn’s disease study


Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy

CHOP versus GEM-P in previously untreated patients with peripheral T-cell lymphoma (CHEMO-T): a phase 2, multicentre, randomised, open-label trial

GAZELLE Study- Obinutuzumab short-duration infusion (SDI) in previously untreated advanced follicular lymphoma Roche – Roche’s Gazyvaro shorter 90-minute infusion time approved in Europe for people with previously treated or untreated follicular lymphoma


Hepatitis E virus in patients with decompensated chronic liver disease: a prospective UK/French study.

Steroids or Pentoxifylline for Alcoholic Hepatitis (STOPAH) trial

Neurology- Multiple Sclerosis

The Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) trial: a randomised double-blind placebo-controlled parallel-group multicentre trial and economic evaluation of cannabinoids to slow progression in multiple sclerosis.

Towards a better understanding of MS pain: a systematic review of potentially modifiable psychosocial factors.


Intracranial Efficacy and Survival With Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2-Positive Breast Cancer With Brain Metastases in the HER2CLIMB Trial

FAST-Forward: Randomised clinical trial testing a 1-week course of curative whole breast radiotherapy against a standard 3-week schedule in terms of local cancer control and late adverse effects in patients with early breast cancer.

The POUT trial: PeriOperative chemotherapy or sUrveillance in upper Tract urothelial cancer

The PAKT Trial: Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer

Neoadjuvant/Adjuvant Phase 3 KEYNOTE-522 (Early-Stage Triple-Negative Breast Cancer Trial)

Trial of intraoperative cell salvage versus transfusion in ovarian cancer (TIC TOC): protocol for a randomised controlled feasibility study.

Body mass index and sexual function in women with gynaecological cancer

AspECT A Phase III randomised study of aspirin and esomeprazole chemoprevention in Bareett’s metaplasia

Randomized Phase II Study Evaluating Palbociclib in Addition to Letrozole as Neoadjuvant Therapy in Estrogen Receptor–Positive Early Breast Cancer: PALLET Trial.

Esomeprazole and aspirin in Barrett’s oesophagus (AspECT): a randomised factorial trial

Intermittent chemotherapy plus either intermittent or continuous cetuximab for first-line treatment of patients with KRAS wild-type advanced colorectal cancer (COIN-B): a randomised phase 2 trial

Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial

3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT): an international, randomised, phase 3, non-inferiority trial

PARSIFAL Study: Looking at the effect and safety of palbociclibin in combination with two different endocrine treatments in patients with ER+, HER negative locally advanced or metastatic breast cancer.
Fulvestrant-Palbociclib vs Letrozole-Palbociclib as Initial Therapy for Endocrine-Sensitive, Hormone Receptor–Positive, ERBB2-Negative Advanced Breast Cancer: A Randomized Clinical Trial | Breast Cancer | JAMA Oncology | JAMA Network

Peruse- A Study of Pertuzumab in Combination with Trastuzumab (Herceptin) and a Taxane in First-Line Treatment in Participants with HER-2 Postive Advanced Breast Cancer.

Parsifal- Fulvestrant-Palbociclib vs Letrozole-Palbociclib as Initial Therapy for Endocrine-Sensitive, Hormone Receptor–Positive, ERBB2-Negative Advanced Breast Cancer.

UK Prosper- Exercise versus usual care after non-reconstructive breast cancer surgery: multicentre randomised controlled trial and economic evaluation.


Hip arthroscopy versus best conservative care for the treatment of femoroacetabular impingement syndrome (UK FASHIoN): a multicentre randomised controlled trial

HEALTH – Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture

UK Star- Plaster case vs functional brace for non-surgical treatment of Achilles tendon rupture.


MAGNEsium Trial In Children (MAGNETIC): a randomised, placebo-controlled trial and economic evaluation of nebulised magnesium sulphate in acute severe asthma in children

Oxygen saturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial

Early or Delayed Enteral Feeding for Preterm Growth-Restricted Infants: A Randomised Trial ADEPT

Oxygen saturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial

Oxygen Saturation and Outcomes in Preterm Infants (BOOST II)


Renal Medicine

SPEAK study (Surveying People Experiencing young Adult Kidney failure)

PIVOTAL Intravenous Iron in Patients Undergoing Maintenance Hemodialysis


A Survey of Psychological Support Provision for People with Inflammatory Arthritis in Secondary Care in England- PSYSCOPE


REstart or STop Antithrombotics Randomised Trial

Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial

TWIST: Does the Use of Nintendo Wii SportsTM Improve Arm Function? Trial of WiiTM in Stroke: A Randomized Controlled Trial and Economics Analysis


Thulium laser transurethral vaporesection of the prostate versus transurethral resection of the prostate for men with lower urinary tract symptoms or urinary retention (UNBLOCS): a randomised controlled trial

Women’s Health & Obstetrics

VUE- Surgical interventions for uterine prolapse and for vault prolapse

Prednisolone in Nephrotic Syndrome: The PREDNOS Study

Intraoperative cell salvaged blood as part of a blood conservation strategy in Caesarean section: is fetal red cell contamination important?

Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial

Upright versus lying down position in second stage of labour in nulliparous women with low dose epidural: BUMPES randomised controlled trial

NHS Staff Research

Hair today, gone tomorrow: How personal protective equipment guidance changed doctor’s facial hair during the COVID‐19 pandemic


An artificial intelligence deep learning model for identification of small bowel obstruction on plain abdominal radiographs

Links to reports on our performance in delivering research

Feedback about your research experiences

We actively encourage our research participants to give their feedback on their experiences of study participation. This helps us to recognise our staff and improve our service.

To enable us to do this, we hold an annual, snapshot experience survey as well as welcoming feedback through Care Opinion. Care Opinion allows people to anonymously share their experiences, good and bad, of healthcare services across the country. Stories are then passed to department representatives who will review and respond via the website.

Working With Us

Current vacancies for the Royal Cornwall Hospitals, Research & Development Department can be found at NHS jobs.

Links to useful information:

Find out what a career in NHS Research at the Royal Cornwall Hospital could offer you

Researcher Profiles: meet some of the researchers conducting their own studies at the Trust

Laura Royle

Laura Royle

Senior Study Set-up Officer, R&D

Laura began her career in Research & Development as an Administrator in Oncology. Soon she was inspired to complete her MSc thesis on a study looking at the quality of life of people with cancer who have participated in research.

Laura explains: “This was the first study of mine that required Health Research Authority approval and all that this entails. It was a steep learning curve, but the assistance of the study set-up team and the governance team was fantastic. I was supported and encouraged every step of the way”. Laura is now planning her second piece of research at the Trust, looking at the running of health research during the pandemic.

Mr Alexandros Hadjiantoni

Chief Cardiac Physiologist

Alex is undertaking his study as part of his PhD in Biomedical Science. The purpose of the MAAP Trial is the clinical evaluation of a High-Sensitivity 12 lead Electrocardiogram, for patients presenting with cardiac chest pain. The study comes with benefits to the patient which include early diagnosis of heart disease, a reduction in illness and death on top of reduced costs to the NHS.

Alex said “The Research Team have provided me with no end of support, guidance and advice, and always a smile. I would encourage anyone to undertake research and a PhD. Be resourceful and confident that the right people will guide you on your journey”.

Alexandros Hadjiantoni
Fangyi Xie

Fangyi Xie

Dermatology Registrar

Fangyi, has played a major role in a project using photodynamic therapy. This is a form of light treatment using a photosensitizer to treat precancerous skin lesions and basal cell carcinomas. The single centre clinical trial aims to see whether changing the duration of application of the photosensitizer improves the outcome for patients with a precancerous form of sun damage.

Fangyi says she has had a brilliant and very educational experience so far, and would recommend anyone to consider setting up their own research. ​

Chrissy Eade

Consultant Plain Film Radiographer

Chrissy qualified as a diagnostic radiographer from the University of the West of England in 1999. She had always wanted to develop a clinical patient facing role whilst also achieving academically through teaching and research.

Currently, Chrissy is working with a research team from the University of Exeter who are studying x-rays of children aged 24 months and under. The project aims to look at certain types of bone fractures in young children. It will see if the latest ‘artificial intelligence’ technology can help detect physical abuse as a cause. The need to develop radiology diagnosis nationally and to improve the clinical pathway to keep our local children safe are Chrissy’s primary motivators for the research.

Chrissy Eade
Leonie Glinski

Leonie Glinski

Senior Biomedical Scientist in Cytopathology

Executive for the British Association of Cytopathology

Leonie has been actively involved in cancer related research for nearly two decades. She has contributed to research that results in services at RCHT attracting national and international recognition as best practice. Leonie is currently involved in trials that ensure patients in Cornwall continue to receive advanced diagnostic services.

Leonie says “I am passionate about cytopathology services and I’m motivated further by working collaboratively with the great and enthusiastic management, laboratory staff and research teams at RCHT. Each area shares the fundamental goals of improving patient pathways and care outcomes and brings their wealth of knowledge and expertise to the fore. I believe this is the key to successful research and innovation and I’m so delighted to be part of it”.

Mary Jones

Chartered Scientist

Mary works in the pathology department specialising in immunohistochemistry and molecular biology for histology and cytology specimens. She has supported multiple departmental projects and been a primary author for several professional journal articles.

Mary said “The R&D team provide fantastic support and training for all research being undertaken in the Trust. The foundation of my practices and skills were obtained on a five-day residential course held in France. Many of the research projects undertaken in pathology have directly led to improvements for cancer patients in Cornwall and include multiple team collaborations. The ongoing and future research in my department entails  the search for techniques to allow more treatment options for cancer patients using smaller and less invasive samples from patients”.

Mary Jones
Daniel Kim

Dr Daniel Kim

Consultant Radiologist

Dr Daniel Kim is a consultant radiologist, sub-specialising in gastrointestinal imaging with a research interest in artificial intelligence (AI). Dr Kim has a combined medical and computational background with degrees in Computation Biology (BSc), Bioinformatics (MSc) and Medicine (MBChB). This has provided the platform from which to conduct AI research in topics such as fracture detection and diagnosis of Parkinson’s disease. He also has experience in industry investigating the use of Radiomics in liver imaging.

Dr Kim is currently supporting the National Consortium of Intelligent Medical Imaging with various AI research projects hosted here at RCHT. He also has ongoing research investigating the use of AI for faster diagnosis of bowel obstruction and for enhanced MRI safety. In the future Dr Kim aims to promote the integration and validation of AI in standard clinical pathways and is open to further collaboration with clinical colleagues, academia and industry.

Dr Kim says “Artificial Intelligence is a fascinating discipline that has huge potential to improve patient outcomes. I am excited by the prospect of further developments in this field and by the opportunity to contribute with research here at RCHT. The assistance and direction from the research department at RCHT has been excellent. They have been very supportive and willing to work together to reach the goal of improving patient care through research. This has made research at RCHT particularly productive and enjoyable.”

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