Research, Development & Innovation

The Royal Cornwall Hospitals Research, Development and Innovation department supports and facilitates health research in Cornwall. Research is a hugely important part of what we do at the Royal Cornwall Hospitals. It gives us new knowledge about how to treat and care for patients with different health conditions and helps us to provide our patients with the best and most appropriate care possible.
We are dedicated to developing ground breaking treatments, technologies and techniques as well as meeting your needs and identifying the best use of resources.

More about the department

How we approve research and make sure it is safe

  • The NHS Research Governance Framework sets out the standards by which research is conducted, including the monitoring of protocols and procedures to make sure that these are followed.
  • Any research we carry out must meet recognised ethical standards and respect the dignity, rights, safety and well-being of the people who take part.
  • These standards must be assessed and approved by an independent Research Ethics Committee (REC)

Links to further information on clinical research

Patient Information and health and care research

https://www.hra.nhs.uk/information-about-patients/

Newsletters


Links to some of our previous studies

Please see below sample of published research results from some of the studies that the Royal Cornwall Hospitals Trust have been involved in. We are aiming to increase the number available on this webpage in the future.

Please note there is often a significant time lag between the end of patient participation in a study and the availability of the results.

Oncology

Randomized Phase II Study Evaluating Palbociclib in Addition to Letrozole as Neoadjuvant Therapy in Estrogen Receptor–Positive Early Breast Cancer: PALLET Trial
http://ascopubs.org/doi/full/10.1200/JCO.18.01624

Esomeprazole and aspirin in Barrett’s oesophagus (AspECT): a randomised factorial trial
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31388-6/fulltext

Renal Medicine

SPEAK study (Surveying People Experiencing young Adult Kidney failure)
https://www.ajkd.org/article/S0272-6386(18)30906-5/fulltext

Cardiology

HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/ laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment
http://epadruginitiative.com/files/HPS2_THRIVE_Study.pdf

Rehabilitation Enablement in Chronic Heart Failure (REACH-HF)
https://www.royalcornwall.nhs.uk/services/research-development-innovation/rehabilitation-enablement-chronic-heart-failure-reach-hf/

Critical Care

Risk Adjustment In Neurocritical care (RAIN)–prospective validation of risk prediction models for adult patients with acute traumatic brain injury to use to evaluate the optimum location and comparative costs of neurocritical care: a cohort study.
https://www.ncbi.nlm.nih.gov/pubmed/23763763

Dermatology

Effect of Topical Imiquimod as Primary Treatment for Lentigo Maligna: The LIMIT-1 Study
https://www.ncbi.nlm.nih.gov/labs/articles/27714781/

Diabetes

ALTITUDE: ALiskiren Trail in T2 Diabetes using cardiorenal endpoints
https://clinicaltrials.gov/ct2/show/results/NCT00549757

ADDRESS 2- Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort
https://bmjopen.bmj.com/content/8/4/e020904

Emergency Medicine

Randomised Evaluation of modified Valsalva Effectiveness in Re-entrant Tachycardias (REVERT) study.
https://www.ncbi.nlm.nih.gov/pubmed/24622951

Haematology

Myeloma XI- Randomised comparisons in myeloma patients of all ages of thalidomide, lenalidomide and bortezomib combinations and maintenance lenalidomide
https://www.myeloma.org.uk/news/myeloma-xi-trial-results-show-significant-increase-in-myeloma-patient-remission/

Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy
http://www.nejm.org/doi/full/10.1056/NEJMoa1616569

CHOP versus GEM-P in previously untreated patients with peripheral T-cell lymphoma (CHEMO-T): a phase 2, multicentre, randomised, open-label trial
https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(18)30039-5/abstract

Hepatology

Hepatitis E virus in patients with decompensated chronic liver disease: a prospective UK/French study.
https://www.ncbi.nlm.nih.gov/pubmed/26174470

Steroids or Pentoxifylline for Alcoholic Hepatitis (STOPAH) trial
http://www.medscape.com/viewarticle/834928

Neurology- Multiple Sclerosis

The Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) trial: a randomised double-blind placebo-controlled parallel-group multicentre trial and economic evaluation of cannabinoids to slow progression in multiple sclerosis.
https://www.ncbi.nlm.nih.gov/pubmed/25676540

Towards a better understanding of MS pain: a systematic review of potentially modifiable psychosocial factors.
https://www.ncbi.nlm.nih.gov/pubmed/25438982

Oncology

Intermittent chemotherapy plus either intermittent or continuous cetuximab for first-line treatment of patients with KRAS wild-type advanced colorectal cancer (COIN-B): a randomised phase 2 trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012566/

Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159416/

3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT): an international, randomised, phase 3, non-inferiority trial
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30093-7/fulltext?code=lancet-site

Orthopaedics

Hip arthroscopy versus best conservative care for the treatment of femoroacetabular impingement syndrome (UK FASHIoN): a multicentre randomised controlled trial
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31202-9/fulltext

Paediatrics

MAGNEsium Trial In Children (MAGNETIC): a randomised, placebo-controlled trial and economic evaluation of nebulised magnesium sulphate in acute severe asthma in children
https://www.ncbi.nlm.nih.gov/pubmed/24144222

Oxygen saturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00163-4/fulltext?rss=yes

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32456-X/abstract?code=lancet-site

Rheumatology

A Survey of Psychological Support Provision for People with Inflammatory Arthritis in Secondary Care in England- PSYSCOPE
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282402/

Stroke

Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial
http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)70018-9/abstract

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61121-1/abstract

TWIST: Does the Use of Nintendo Wii SportsTM Improve Arm Function? Trial of WiiTM in Stroke: A Randomized Controlled Trial and Economics Analysis
https://www.ncbi.nlm.nih.gov/labs/articles/26975313/

Women’s Health & Obstetrics

Intraoperative cell salvaged blood as part of a blood conservation strategy in Caesarean section: is fetal red cell contamination important?
https://www.ncbi.nlm.nih.gov/pubmed/21676894

Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00724-2/abstract

Upright versus lying down position in second stage of labour in nulliparous women with low dose epidural: BUMPES randomised controlled trial http://www.bmj.com/content/359/bmj.j4471

Early or Delayed Enteral Feeding for Preterm Growth-Restricted Infants: A Randomised Trial ADEPT http://pediatrics.aappublications.org/content/early/2012/04/04/peds.2011-2379

Oxygen saturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00163-4/fulltext

Oxygen Saturation and Outcomes in Preterm Infants (BOOST II)
http://www.nejm.org/doi/full/10.1056/NEJMoa1302298#t=article

Links to reports on our performance in delivering research

NIHR Activity Research League Table

RESEARCH NEWS, EVENTS & AWARDS
News / General News / Patient Care

CQC report shows improvement underway at RCHT

Published: December 14, 2018

Categories: News / General News / Patient Care

Staff at the Royal Cornwall Hospitals have welcomed today’s report from the Care Quality Commission which has seen the Trust move its rating from ‘Inadequate’ to ‘Requires Improvement’.

News / Cancer Services / Clinical Imaging / Patient Experience

£40 million investment in Cornwall’s NHS

Published: December 12, 2018

Categories: News / Cancer Services / Clinical Imaging / Patient Experience

More than £40 million to be spent improving Cornwall’s hospitals and healthcare as part of major transformation programme. Health leaders in Cornwall welcomed the news today that more than £40 million is to be invested in key hospital and healthcare projects in the county. The funding, part of the government’s long term plan for the […]

News / General News / Patient Care

CQC report shows improvement underway at RCHT

Published: December 14, 2018

Categories: News / General News / Patient Care

Staff at the Royal Cornwall Hospitals have welcomed today’s report from the Care Quality Commission which has seen the Trust move its rating from ‘Inadequate’ to ‘Requires Improvement’.