Research, Development & Innovation

Providing new knowledge and helping us provide the best possible care.

The Royal Cornwall Hospitals Research, Development and Innovation department supports and facilitates health research in Cornwall. Research is a hugely important part of what we do at the Royal Cornwall Hospitals. It gives us new knowledge about how to treat and care for patients with different health conditions and helps us to provide our patients with the best and most appropriate care possible.
We are dedicated to developing ground breaking treatments, technologies and techniques as well as meeting your needs and identifying the best use of resources.

More about the department

Find out how our research team is helping improve rehabilitation for people with chronic heart failure

How we approve research and make sure it is safe

  • The NHS Research Governance Framework sets out the standards by which research is conducted, including the monitoring of protocols and procedures to make sure that these are followed.
  • Any research we carry out must meet recognised ethical standards and respect the dignity, rights, safety and well-being of the people who take part.
  • These standards must be assessed and approved by an independent Research Ethics Committee (REC)

Links to further information on clinical research

Patient Information and health and care research


Links to some of our previous studies

Please see below sample of published research results from some of the studies that the Royal Cornwall Hospitals Trust have been involved in. We are aiming to increase the number available on this webpage in the future.

Please note there is often a significant time lag between the end of patient participation in a study and the availability of the results.


HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/ laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment
Rehabilitation Enablement in Chronic Heart Failure (REACH-HF)

Critical Care

Risk Adjustment In Neurocritical care (RAIN)–prospective validation of risk prediction models for adult patients with acute traumatic brain injury to use to evaluate the optimum location and comparative costs of neurocritical care: a cohort study.


Effect of Topical Imiquimod as Primary Treatment for Lentigo Maligna: The LIMIT-1 Study


ALTITUDE: ALiskiren Trail in T2 Diabetes using cardiorenal endpoints

ADDRESS 2- Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort

Emergency Medicine

Randomised Evaluation of modified Valsalva Effectiveness in Re-entrant Tachycardias (REVERT) study.


Myeloma XI- Randomised comparisons in myeloma patients of all ages of thalidomide, lenalidomide and bortezomib combinations and maintenance lenalidomide

Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy

CHOP versus GEM-P in previously untreated patients with peripheral T-cell lymphoma (CHEMO-T): a phase 2, multicentre, randomised, open-label trial


Hepatitis E virus in patients with decompensated chronic liver disease: a prospective UK/French study.

Steroids or Pentoxifylline for Alcoholic Hepatitis (STOPAH) trial

Neurology- Multiple Sclerosis

The Cannabinoid Use in Progressive Inflammatory brain Disease (CUPID) trial: a randomised double-blind placebo-controlled parallel-group multicentre trial and economic evaluation of cannabinoids to slow progression in multiple sclerosis.

Towards a better understanding of MS pain: a systematic review of potentially modifiable psychosocial factors.


Intermittent chemotherapy plus either intermittent or continuous cetuximab for first-line treatment of patients with KRAS wild-type advanced colorectal cancer (COIN-B): a randomised phase 2 trial

Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial

3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT): an international, randomised, phase 3, non-inferiority trial


Hip arthroscopy versus best conservative care for the treatment of femoroacetabular impingement syndrome (UK FASHIoN): a multicentre randomised controlled trial


MAGNEsium Trial In Children (MAGNETIC): a randomised, placebo-controlled trial and economic evaluation of nebulised magnesium sulphate in acute severe asthma in children

Oxygen saturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial


A Survey of Psychological Support Provision for People with Inflammatory Arthritis in Secondary Care in England- PSYSCOPE


Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial

TWIST: Does the Use of Nintendo Wii SportsTM Improve Arm Function? Trial of WiiTM in Stroke: A Randomized Controlled Trial and Economics Analysis

Women’s Health & Obstetrics

Intraoperative cell salvaged blood as part of a blood conservation strategy in Caesarean section: is fetal red cell contamination important?

Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial

Upright versus lying down position in second stage of labour in nulliparous women with low dose epidural: BUMPES randomised controlled trial

Early or Delayed Enteral Feeding for Preterm Growth-Restricted Infants: A Randomised Trial ADEPT

Oxygen saturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial

Oxygen Saturation and Outcomes in Preterm Infants (BOOST II)

Links to reports on our performance in delivering research

NIHR Activity Research League Table

News / RCHT Charity / Research

Second Chance for Cancer Research in Cornwall

Published: September 20, 2018

Categories: News / RCHT Charity / Research

Donating unwanted items to Long Rock’s new charity shop can help cancer research projects right here in Cornwall.

News / Cancer Services / Research

New research facility opens at Sunrise Centre

Published: July 26, 2017

Categories: News / Cancer Services / Research

Cancer patients in Cornwall will now have even wider opportunities to access the latest treatments and take part in cancer trials with the opening

Award / Awards and Achievements / Research

Nurse’s research to investigate domestic abuse in older people

Published: May 25, 2018

Categories: Award / Awards and Achievements / Research

A nurse who specialises in safeguarding has won a grant to explore domestic abuse in older people.